Figure 5.

Molecular Interactions between Echo 6 Virus and FcRn/CD55 Receptors

(A) The atomic model of Echo 6-FcRn in the main contacting interface. The viral proteins are shown in surface models, and the receptor is represented as ribbon model. VP1, VP2, and VP3 of Echo 6 are shown in green, cyan, and magenta, respectively. The interacting FCGRT subunit of FcRn is colored in orange. The “canyon” is indicated by a red asterisk.

(B) The interaction details between Echo 6 virus and FcRn receptor. The proteins are colored by chains as in (A), and the contacting residues are shown as sticks and colored by elements. Hydrogen bonds are represented by black dashed lines.

(C) The atomic model of the Echo 6-CD55 in the main contacting interface. The viral proteins (colored by chains) are shown in surface models, and CD55 (blue) is represented as ribbons. The interaction is mainly mediated by the SCR3 and SCR4 domains.

(D) The interaction details between Echo 6 virus and CD55 in the same style of FcRn in (B).

See also Figure S7.