Figure S7.

Comprehensive Comparison of CD55 and FcRn Binding Sites on Different Enteroviruses, Related to Figure 5

(A) Cartoon diagrams of CD55 bound to different enteroviruses determined by cryo-EM. Each component is represented with a unique color, and CD55 is colored in gold.

(B) Superimposition of the atomic models of CD55 bound to different enteroviruses within an asymmetric unit. The icosahedral axes are shown as triangles and pentangles. The binding site of CD55 on Echo 6 virus is similar to that on CV-B3, but different from those on the Echo 7 and Echo 12 viruses. The “canyon” is indicated by a red asterisk.

(C) Comparison of the binding sites of CD55 and FcRn on Echo 6 virus. The viral proteins are shown in surface models, and the receptors are shown as ribbons. The position of the “canyon” is indicated by a red asterisk. The steric clash between CD55 and FcRn is highlighted by a dashed oval.

(D) Comparison of the binding sites of CD55 and FcRn on Echo 7 virus. The two receptors could bind simultaneously on the virus without clashing. Two different views of the superimposition are shown to reveal the compatibility of the two receptors in space.

VP1, VP2 and VP3 of the virus are shown in green, cyan and magenta, respectively. CD55 molecules bound to Echo 6, Echo 7, Echo 12 and CV-B3 are shown in blue, black, pink and red, respectively. The FCGRT subunit of FcRn is shown in orange, and β2 m is in gray.