Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 May 26;165(6):1467–1478. doi: 10.1016/j.cell.2016.05.022

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 Elsevier Inc.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

PMC Copyright notice

Examination of the Interaction between Cleaved Glycoprotein of Ebola Virus (EBOV-GPcl) and FL NPC1

(A) The interaction between EBOV-GPcl and NPC1 is pH dependent. The binding affinity is measured using SPR.

(B) Docking of the domain C-GPcl complex (PDB: 5F1B) to the EM structure of hNPC1. Right: conformational changes of domain C. Note the pronounced rearrangement of helix α1 of domain C between the crystal structure of isolated domain (silver) and the EM structure of FL protein (green).

(C) The docking model suggested a potential interface between NPC1(NTD) and EBOV-GPcl. The domain C-GPcl1 complex is shown as semi-transparent surface electrostatic potential calculated in PyMol.

(D) The NTD-deleted hNPC1 binds to EBOV-GPcl with similar affinity as FL protein at pH 6.0.