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. 2016 May 26;165(6):1467–1478. doi: 10.1016/j.cell.2016.05.022

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© 2016 Elsevier Inc.

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Figure S2 — Structures of the Individual Lumenal Domains, Related to Figures 1 and 3

(A) Domains C and I of hNPC1 share sequence similarity. The secondary structural elements of domain C is shown on top of the aligned sequences. Invariant and conserved residues are shaded yellow and gray, respectively.

(B) Crystal structures of the NTD and domain C (PDB: 3GKJ and PDB: 5HNS, respectively) were used for rigid body docking into the EM map with manual adjustment. A homologous model of domain I was generated based on domain C.

(C) Structural similarity of domains C and I with the periplasmic porter domains of AcrB. The core regions of domains C and I composed of the β sheet and two helices can be superimposed to the porter domains of AcrB.