Skip to main content
. 2013 Nov 21;22(1):292–302. doi: 10.1016/j.bmc.2013.11.028

Table 3.

Inhibitory activities of compound 8 against SARS CoV 3CLpro

graphic file with name fx17.jpg

Compound R2 R3 IC50 (μM)
8a1 graphic file with name fx18.gif CH3 11.83 ± 1.87
8a2 PhCH2 67.20 ± 8.50
8a3 β-C10H7CH2 82.91 ± 12.91
8b2 graphic file with name fx19.gif PhCH2 ND
8b3 β-C10H7CH2 ND
8d2 graphic file with name fx20.gif CH3 ND
8d3 PhCH2 ND
8f1 graphic file with name fx21.gif β-C10H7CH2 13.86 ± 
8f2 CH3 ND
8f3 PhCH2 ND
8h1 graphic file with name fx22.gif β-C10H7CH2 5.52 ± 0.33
8h2 CH3 ND
8h3 PhCH2 ND
8i2 graphic file with name fx23.gif β-C10H7CH2 14.00 ± 2.472
8i3 β-C10H7CH2 ND
8j1 graphic file with name fx24.gif CH3 9.91 ± 0.79
8j2 PhCH2 13.86 ± 2.96
8j3 β-C10H7CH2 39.87 ± 0.62
8k1 graphic file with name fx25.gif PhCH2 1.04 ± 0.01
8k2 β-C10H7CH2 1.69 ± 0.01
8k3 CH3 17.82 ± 0.72
8m1 graphic file with name fx26.gif PhCH2 2.82 ± 0.17
8m2 β-C10H7CH2 4.70 ± 0.12
8m3 PhCH2 ND

ND: not done because of quenching rate >20%.