Scheme 13.
Potent anticancer agents. Reagents and conditions: (i) phenylpropiolaldehyde diethyl acetal (1 eq.) or 4-phenylbut-3yn-2-one (1 eq.), PTSA (0.1 eq.), EtOH, reflux, 2–20 h, (ii) CuI, Et3N, MeCN, 82 °C, 1–4 h, (iii) 20% PTSA/MeCN, 1 h.
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