Grande 2000.

Methods	RCT
Participants	Requiring terminal care: treatment = 186 (87% with a diagnosis of cancer); control = 43 (86% with a diagnosis of cancer) Living alone: treatment 21%, control 17% Mean age: treatment 72 (SD 11); control 73 (SD 14) Male 50%, female 54% Survival from referral for both groups: a median of 11 days
Interventions	Referred from primary or secondary care 6 qualified nurses, 2 nursing aides, a co‐ordinator (RGN level), agency staff providing 24‐hour care if required for a maximum of 2 weeks, most had Marie Curie experience Intervention participants could also access standard care Control group received standard care: hospital care or hospice care, with input from the GP and district nurses, Marie Curie nursing, Macmillan nursing, social services, and private nursing
Outcomes	Symptoms and support, GP visits, place of death, and admission to hospital
Notes	UK study
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	4:1 randomisation ratio (HAH:control) to ensure sufficient admissions to hospital at home. Random numbers from a random number table were used
Allocation concealment (selection bias)	Low risk	Allocation for each referral was assigned by the researcher using a random number table and concealed in sequentially numbered, opaque, sealed envelopes
Blinding (performance bias and detection bias) All outcomes	High risk	It was not possible for participants to be blinded to the intervention, hence there is a risk that intervention status may have biased place of death decisions. Low risk for mortality
Incomplete outcome data (attrition bias) All outcomes	Low risk	Response rates: 144/198 (73%) for caregivers, 225/228 (99%) district nurses, 194/228 (85%) primary care physicians
Selective reporting (reporting bias)	Low risk	All stated outcomes reported
Baseline measures	Low risk	Demographic data
Protection against contamination	High risk	Intervention was contaminated by other input available to the control group (e.g. supplemented by GP and other community care when less than 24‐hour hospital‐at‐home input was provided)