Table 2. Genetic analysis findings (n=201).
| Genotypes and haplotypes | n (%) | p-value* |
|---|---|---|
| APOE haplotypes | ||
| ɛ4/ɛ4 | 23 (11.4) | - |
| ɛ4/ɛ3 | 78 (38.8) | - |
| ɛ4/ɛ2 | 7 (3.5) | - |
| ɛ3/ɛ3 | 83 (41.3) | - |
| ɛ3/ɛ2 | 10 (5.0) | - |
| ɛ2/ɛ2 | 0 (0.0) | - |
| rs1800764 genotypes | ||
| CC | 53 (26.4) | 0.291 |
| CT | 93 (46.3) | |
| TT | 55 (27.3) | |
| rs4291 genotypes | ||
| AA | 93 (46.3) | 0.245 |
| AT | 82 (40.8) | |
| TT | 26 (12.9) | |
| ACE haplotypes | ||
| rs1800764 CC/rs4291 AA | 7 (3.5) | - |
| rs1800764 CC/rs4291 AT | 20 (10.0) | - |
| rs1800764 CC/rs4291 TT | 26 (12.9) | - |
| rs1800764 CT/rs4291 AA | 31 (15.4) | - |
| rs1800764 CT/rs4291 AT | 62 (30.9) | - |
| rs1800764 CT/rs4291 TT | 0 (0.0) | - |
| rs1800764 TT/rs4291 AA | 55 (27.3) | - |
| rs1800764 TT/rs4291 AT | 0 (0.0) | - |
| rs1800764 TT/rs4291 TT | 0 (0.0) | - |
| rs11669576 genotypes (LDLR8) | ||
| AA | 2 (1.0) | 0.425 |
| AG | 27 (13.4) | |
| GG | 172 (85.6) | |
| rs5930 genotypes (LDLR10) | ||
| AA | 23 (11.4) | 0.593 |
| AG | 95 (47.3) | |
| GG | 83 (41.3) | |
| LDLR haplotypes | ||
| rs11669576 AA/rs5930 AA | 0 (0.0) | - |
| rs11669576 AA/rs5930 AG | 0 (0.0) | - |
| rs11669576 AA/rs5930 GG | 2 (1.0) | - |
| rs11669576 AG/rs5930 AA | 0 (0.0) | - |
| rs11669576 AG/rs5930 AG | 10 (5.0) | - |
| rs11669576 AG/rs5930 GG | 17 (8.5) | - |
| rs11669576 GG/rs5930 AA | 23 (11.4) | - |
| rs11669576 GG/rs5930 AG | 85 (42.3) | - |
| rs11669576 GG/rs5930 GG | 64 (31.8) | - |
| rs2695121 genotypes (NR1H2 gene) | ||
| CC | 76 (37.8) | 0.691 |
| CT | 93 (46.3) | |
| TT | 32 (15.9) | |
| rs5882 genotypes (CETP gene) | ||
| AA | 75 (37.3) | 0.412 |
| AG | 100 (49.8) | |
| GG | 26 (12.9) | |
| rs708272 genotypes (CETP gene) | ||
| AA | 21 (10.5) | 0.058 |
| AG | 106 (52.7) | |
| GG | 74 (36.8) | |
| CETP haplotypes | ||
| rs5882 AA/rs708272 AA | 3 (1.5) | - |
| rs5882 AA/rs708272 AG | 38 (18.9) | - |
| rs5882 AA/rs708272 GG | 34 (16.9) | - |
| rs5882 AG/rs708272 AA | 11 (5.5) | - |
| rs5882 AG/rs708272 AG | 56 (27.8) | - |
| rs5882 AG/rs708272 GG | 33 (16.4) | - |
| rs5882 GG/rs708272 AA | 7 (3.5) | - |
| rs5882 GG/rs708272 AG | 12 (6.0) | - |
| rs5882 GG/rs708272 GG | 7 (3.5) | - |
ACE = angiotensin-converting enzyme gene; APOE = apolipoprotein E gene; CETP = cholesteryl ester transfer protein gene; LDLR = low-density lipoprotein cholesterol receptor gene; NR1H2 = liver X receptor beta gene.
*
Hardy-Weinberg equilibrium (chi-square test).