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. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: FASEB J. 2019 Dec 13;34(2):2105–2125. doi: 10.1096/fj.201900677R

Figure 8. Diagram of the role of C3ar1/C5ar1 and IL-6R-gp130 co-signaling in RTK function and potentially broad relevance.

Figure 8.

(A). Diagram explaining the requirement of coordinate C3ar1/C5ar1 and IL-6R-gp130 signaling to lift dominant restraint on RTK signaling. C3ar1/C5ar1 and IL-6R co-signaling is needed to lift dominate restraint (the brake) on RTK signaling (throttle). (B) Cartoon of signaling interconnections. When C3ar1/C5ar1 or IL-6R-gp130 signaling is absent, RTK mitotic function is blocked despite occupation of GF. (C) Data implicating the requirement of this signaling interconnection in the function of other RTKs: IGF= insulin dependent growth factor, FGF=fibroblast growth factor, NGF= nerve growth factor, GM-CSF=granulocyte-monocyte colony stimulating factor.