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. 2019 Apr 4;167:68–77. doi: 10.1016/j.antiviral.2019.03.014

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Fig. 1 — Identification of losmapimod as a LASV entry inhibitor by clinical compound library screening. (A) Screening flowchart. (B) The chemical structure of losmapimod. (C) The effects of losmapimod on LASV-GP/HIV-luc and VSV-G/HIV-luc pseudovirus infection, as well as cell viability. The EC₅₀, CC₅₀ and SI values for losmapimod against LASV-GP/HIV-luc are provided. Library screening and losmapimod infectivity and cell viability assays were conducted using HEK293T cells.