Fig. 3.

Losmapimod blocked LASV entry at the stage of post-attachment. Losmapimod, bafilomycin A1 and solvent control DMSO were added to the U-87MG cells as indicated. The infectivity of virus was determined 48 h post infection by measurement of luciferase activity. The experiments were repeated twice, and similar results were obtained. Statistical significance between two groups was calculated by Student's t-test using GraphPad Prism software, with statistical significance set at *P < 0.05 and **P < 0.01. ns: not significant (P ≥ 0.05).