. 2016 Jan 29;24(6):1241–1254. doi: 10.1016/j.bmc.2016.01.052

Table 4.

Inhibitory activities of 5a and cinnamoy-l-serine derivatives (6a–o) with modification at the P′1 position

Entry	Compd	R₃	IC₅₀^a	C log P^b	Entry	Compd	IC₅₀^a	C log P^b
1	5a	H	1500	2.233	10	6i	250	4.312
2	6a		>3200	1.485	11	6j	180	3.382
3	6b		>1600	2.116	12	6k	175	3.482
4	6c		650	4.187	13	6l	170	4.584
5	6d		650	4.748	14	3	125	4.826
6	6e		560	3.482	15	6m	120	5.226
7	6f		550	6.085	16	6n	85	5.284
8	6g		450	4.367	17	6o	65	4.878
9	6h		400	3.129

μM.

C log P was calculated by ChemBio3D Ultra 12.0 (PerkinElmer).