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. 2016 Jan 29;24(6):1241–1254. doi: 10.1016/j.bmc.2016.01.052

Table 5.

Inhibitory activities of benzoyl-l-serine derivatives (7b–k) with modification at the P4 position

graphic file with name fx63_lrg.jpg

Entry Compd R2 IC50a C log Pb Entry Compd R2 IC50a C log Pb
1 7b graphic file with name fx64_lrg.gif >3200 2.955 6 7g graphic file with name fx69_lrg.gif 154 4.484
2 7c graphic file with name fx65_lrg.gif 500 4.673 7 7h graphic file with name fx70_lrg.gif 100 4.484
3 7d graphic file with name fx66_lrg.gif 240 4.745 8 7i graphic file with name fx71_lrg.gif 98 4.745
4 7e graphic file with name fx67_lrg.gif 220 3.968 9 7j graphic file with name fx72_lrg.gif 95 6.304
5 7f graphic file with name fx68_lrg.gif 155 4.745 10 7k graphic file with name fx73_lrg.gif 74 4.126
a

μM.

b

C log P was calculated by ChemBio3D Ultra 12.0 (PerkinElmer).