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. 2020 Mar;30(3):447–458. doi: 10.1101/gr.257832.119

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© 2020 Rowley et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 3. — SIP and SIPMeta can be used to detect and analyze loops in different species. (A) Example locus for SIP loops detected in Hi-C for D. melanogaster. (B) Left: Metaplot of SIP loops illustrating that the Manhattan distance between a and b is different with respect to loops but is visually depicted as the same distance in square metaplots. (L) left anchor, (R) right anchor. Right: Metaplot of SIP loops illustrating the bullseye transformation performed by SIPMeta. (C) Left: Example locus in GM12878 cells for a stripe detected in Hi-C maps of mammals. Right: SIPMeta plots displaying how stripes appear in square versus bullseye plots. (D) Enrichment of CTCF motifs on loop anchors in D. melanogaster, A. aegypti, and H. sapiens.