Table 3.

Comparison of the risk of composite outcome vascular event, ischemic stroke/TIA and all-cause mortality in patients with MES-positive compared with MES-negative using Cox proportional hazard regression.

	Recurrent Ischemic Stroke or TIA			*Composite Outcome			All-cause Mortality
	Unadjusted analysis
	n	HR (95% CI)	P value	n	HR (95% CI)	P value	N	HR (95% CI)	P value
MES-positive	7	5.78 (1.20–27.9)	0.03	8	4.50 (1.19–16.9)	0.03	2	0.38 (0.08–1.82)	0.29
MES-negative	2	Reference		3	reference		8	reference
	†Adjusted analysis
	n	HR (95% CI)	P value	n	HR (95% CI)	P value	N	HR (95% CI)	P value
MES-positive	7	8.22 (1.55 – 43.6)	0.01	8	6.73 (1.63–27.8)	0.01	2	0.40 (0.07–2.27)	0.30
MES-negative	2	reference		3	reference		8	reference

Abbreviations: CI = confidence interval; HR = Hazard Ratio; MES = Microembolic Signals; TIA = transient ischemic attack

^*Composite outcome: ischemic stroke, TIA, systemic embolism

^†Cox-Hazards regression model adjusted to unbalanced baseline differences between MES groups by probability score matching – age, smoking, National Institutes of Health Stroke Scale (NIHSS) scores, cholesterol level, Trial of ORG 10172 in Acute Stroke Treatment (TOAST) classification, ASPECTS, last-seen-well to recanalization time.