Table 1.

Conversion factors for calculating total LED for commonly used agents


Drug Class	Drug (D)	Conversion Factor/Ratio	Example	Calculated LED of the Example
l‐dopa	IR l‐dopa	DD × 1	100 mg D tid	300 mg
	CR l‐dopa	DD × 0.75	100 mg D qd	75 mg
	ER l‐dopa	DD × 0.5^c	200 mg D tid	300 mg
	Duodopa	DD × 1.11	7‐mL bolus +4.7 mL/h for 16 hours = 1,644 mg/day	1,825 mg
COMT inhibitors	Entacapone	LD × 0.33^a	200 mg D tid in combination with 100 mg of levodopa tid	100 mg (+300 mg LD)
	Tolcapone	LD × 0.5^a	100 mg D tid in combination with 100 mg of levodopa qid	200 mg (+400 mg LD)
	Opicapone	LD × 0.5^a	50 mg D qd in combination with 100 mg of levodopa qid	200 mg (+400 mg LD)
MAO‐B inhibitors	Selegiline oral	DD × 10	10 mg D qd	100 mg
	Selegiline sublingual	DD × 80	1.25 mg D qd	100 mg
	Rasagiline	DD × 100	1 mg D qd	100 mg
	Safinamide	LED = 100 mg	50 or 100 mg D qd	100 mg
Nonergot‐derived dopamine receptor agonists^b	Apomorphine	DD × 10	5 mg/h for 16 hours = 80 mg/day	800 mg
	Piribedil	DD × 1	50 mg D tid	150 mg
	Pramipexole, ER/IR	DD × 100	2,1 mg D ER qd	210 mg
	Ropinirole, ER/IR	DD × 20	4 mg D tid	240 mg
	Rotigotine	DD × 30	8 mg D qd	240 mg
Other	Amantadine	DD × 1	100 mg D tid	300 mg

Adapted and modified from Tomlinson et al.1

The result is then added to the total daily l‐dopa dose.

For information on ergot‐derived dopamine agonists, refer to Table 1 in Tomlinson et al.1

As proposed by Espay et al.5

D, drug; IR, immediate release; CR, controlled release; ER, extended release; DD, daily dose; LD, levodopa dose; qd, once a day; tid, three times a day; qid, four times a day.