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. 2020 Mar 24;26:e920720-1–e920720-14. doi: 10.12659/MSM.920720

Figure 2.

Figure 2

Serum creatinine, BUN and urinary NAG levels in rats after 14 days and 21 days of UUO or sham-operation treatment. Healthy male rats were grouped randomly (n=10 in each group) and UUO model or sham model surgically established. Equal volume of high (H, 325.86 mg/kg body weight), medium (M, 162.93 mg/kg body weight) or low (L, 81.46 mg/kg body weight) dose of RAC as the treatment, was infused to stomach of the UUO rats twice daily by 7 days post-surgery, while equal volume of sterile saline was given that served as the untreated control group (UUO group). Rats received sham-surgery and gavaged with an equal volume of saline were set as the Sham group. After 14- or 21-days post-surgery (7 or 14 days after the RAC treatments), blood and urine were obtained and centrifuged. BUN, Scr, and urinary NAG levels were detected using the corresponding assay kits. (A) Scr, (B) BUN, and (C) urinary NAG levels in the Sham, UUO, UUO+L-RAC, UUO+M-RAC and UUO+H-RAC groups of rats are shown. Data are represented as mean±SD (n=10). * P<0.05 compared with the Sham group, # P<0.05 compared with UUO group. BUN – blood urea nitrogen; Scr – serum creatinine; NAG – N-acetyl-β-D-glucosaminidase; RAC – rhubarb and astragalus capsule; UUO – unilateral ureteral obstruction; SD – standard deviation.