Table 3.
Activity of streptodepsipeptides P11A (2) and P11B (3) inhibiting proliferation of glioma cells (IC50: μM).
| Compounds | Glioma Cells (GC) |
human astrocytes (HA) | |||
|---|---|---|---|---|---|
| U251 | U87-MG | SHG-44 | C6 | ||
| Valinomycin (1) |
7.6 ± 0.7a |
30.0 ± 2.8a |
21.0 ± 2.9a |
24.0 ± 2.0a |
NT |
| P11A (2) | 0.4 ± 0.0 | 0.4 ± 0.0 | 0.3 ± 0.0 | 0.3 ± 0.0 | 9.1 ± 0.2 |
| Ratios of IC50HA/IC50GC |
23 |
23 |
30 |
30 |
|
| P11B (3) | 0.5 ± 0.0 | 0.2 ± 0.0 | 1.4 ± 0.2 | 0.1 ± 0.0 | 3.5 ± 0.5 |
| Ratios of IC50HA/IC50GC |
7 |
18 |
3 |
35 |
|
| Doxorubicin (DOX) | 3.3 ± 0.7 | 0.4 ± 0.0 | 1.9 ± 0.0 | 0.5 ± 0.1 | 8.7 ± 1.2 |
| Ratios of IC50HA/IC50GC | 3 | 22 | 5 | 17 | |
a
The unit of the IC50 values is nM, NT: No testing.