Fig. 1.

Solution structure of VEEV macro domain. (A) Representation of VEEV macro domain NMR solution structure with secondary structure elements labeled. (B) Superposition of ribbon representations of VEEV macro domain solved by NMR spectroscopy (purple) and X-ray diffraction (light blue). (C) Surface rendering of the calculated electrostatic potential of VEEV macro domain generated with the Adaptive Poisson-Boltzmann Solver (APBS) plug-in in PyMOL (Schrödinger, 2010) where blue and red indicate positively and negatively charged regions respectively (scale −3 kT/e to +3 kT/e).