Fig. 3.

Protection from SARS-CoV infection in immunized mice. Balb/c mice were inoculated intranasally with wt VSV, VSV-S, or SARS-CoV. The mice were challenged 4 weeks later with 10⁵ TCID₅₀ SARS-CoV. Two days later, lungs and nasal turbinates were collected, and the viral titers were determined (A). Additional mice were challenged 4 months after immunization with wt VSV, VSV-SARS S, and SARS-CoV. Two days after the challenge, lungs and nasal turbinates were collected and viral titers were determined (B). Limits of detection were 1.5 log₁₀TCID₅₀/g tissue in 10% lung homogenates and 1.8 log₁₀TCID₅₀/g tissue in 5% nasal turbinate homogenates.