Fig. 7.

The CRD of mDC-SIGN harbors amino acids exchanges in the primary and secondary ligand binding site as compared to hDC-SIGN. An alignment of the CRDs of hDC-SIGN and mDC-SIGN is shown. Triangles mark key residues in the primary and circles indicate important residues in the secondary ligand binding site of hDC-SIGN. Amino acid exchanges in the ligand binding sites of mDC-SIGN are boxed. A conserved EPN motif important for binding to mannose containing carbohydrates is marked in bold. The numbering is shown relative to that of the full length proteins.