Fig. 1.

SARS-CoV replication in the respiratory tract of monkeys. Mean titers of virus (expressed as log₁₀ TCID₅₀/ml of sample; y axis) detected on indicated days (x axis) in the upper respiratory tract (left panels, A, C, and E, closed symbols) and lower respiratory tract (right panels, B, D, and F, open symbols) of rhesus (panels A and B, ◆, ◇), cynomolgus (panels C and D, ▴, ▵), and African Green (panels E and F, ■, □) monkeys following intranasal and intratracheal administration of 10⁶ TCID₅₀ of SARS-CoV. Error bars associated with each data point indicate standard error, and the dotted line indicates the lower limit of detection of virus (10^0.5 TCID₅₀/ml).