Table 2.

Comparison of virus titers in NT swabs, TL fluids, and tissue samples collected at necropsy from the respiratory tract of AGMs^a

Monkey ID #	Sacrificed on indicated day post-infection	Virus titer in upper respiratory tractb							Virus titer in lower respiratory tractb
		NT swab on days				Nasal turbinate tissue at necropsy	TL on days		Tracheal tissue at necropsy	Right lungc		Left lungc
		1	2	3	4		2	4		Titer	# samples positive/total	Titer	# samples positive/total
400	2	1.5	<0.5d			5.5	<0.5d		3.5	7.2 ± 0.29	8/8	2.8 ± 0.78	3/4
443	2	<0.5d	<0.5d			3.7	3.2		4.2	4.0 ± 0.36	8/8	2.9 ± 0.41	5/6
420	4	1	3.0	2.2	<0.5d	4.0	<0.5d	<0.5d	2.5	2.3 ± 0.36	5/8	2.2 ± 0.36	3/6
568	4	1.5	1	2.0	<0.5d	3.7	<0.5d	<0.5d	4.0	3.3 ± 0.47	7/8	≤1.5 ± 0d	0/6

^aFour AGMs received 10^6.3 TCID₅₀ of SARS-CoV by intranasal and intratracheal administration on day 0.

^bVirus titers are expressed as log₁₀ TCID₅₀/ml from secretions and as log₁₀ TCID₅₀/g from 10% w/v tissue homogenates.

^cTiters in lung are expressed as mean ± standard error for 4–8 samples obtained from each lobe of the lung.

^dVirus was not detected; the lower limit of detection in tissue homogenates was 10^1.5 TCID₅₀/g and in NT swabs and TL was 10^0.5 TCID₅₀/ml.