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Oxidation of diisopropyl HPMPA (8a) to diisopropyl (S)-CPMEA (9a)
| Oxidative agent; solvent | Desired product | Isolated yield |
|---|---|---|
| KMnO4/KOH; H2O | 9a | Complex mixture |
| I2/K2CO3; MeOH | Methyl ester of 9a | Complex mixture |
| RuO2/NaIO4; MeCN, CH2Cl2, H2O | 9a | 63% |
| TEMPO/BAIB; MeCN, H2O | 9a | 71% |
| TEMPO/NaClO2/NaClO; MeCN, H2O | 9a | 87% |
