Table 2.
Comparison of G + C contents and amino acid identities among the RNA dependent RNA polymerases and helicases of the six novel coronaviruses in bats and those of other coronaviruses
| Coronavirusesa | G + C contents of coronaviruses | Features of the RNA dependent RNA polymerases/Helicases of the six novel bat coronaviruses |
||||||
|---|---|---|---|---|---|---|---|---|
| G + C contents | Pairwise amino acid identity (%) |
|||||||
| Bat-CoV HKU2 | Bat-CoV HKU4 | Bat-CoV HKU5 | Bat-CoV HKU6 | Bat-CoV HKU7 | Bat-CoV HKU8 | |||
| Group 1 | ||||||||
| HCoV-229E | 0.38 | 0.38/0.39 | 81/81 | 58/62 | 57/62 | 78/78 | 80/81 | 74/82 |
| PEDV | 0.42 | 0.40/0.42 | 78/78 | 60/62 | 59/63 | 88/90 | 81/81 | 75/82 |
| TGEV | 0.38 | 0.37/0.38 | 75/77 | 59/61 | 59/61 | 75/75 | 75/73 | 70/74 |
| FeCoV | 0.38 | 0.38/− | 76/− | 60/− | 60/− | 75/− | 75/− | 76/− |
| HCoV-NL63 | 0.34 | 0.34/0.35 | 79/81 | 57/61 | 57/62 | 79/82 | 81/83 | 75/83 |
| Bat-CoV 61–3 | – | 0.39/0.39 | 75/81 | 63/64 | 60/64 | 75/82 | 79/86 | 79/87 |
| Bat-CoV HKU2 | – | 0.39/0.40 | – | 58/61 | 58/62 | 78/78 | 82/80 | 74/81 |
| Bat-CoV HKU6 | – | 0.39/0.39 | 78/78 | 59/63 | 59/63 | – | 82/80 | 76/81 |
| Bat-CoV HKU7 | – | 0.40/0.40 | 82/80 | 59/62 | 59/62 | 82/80 | – | 84/92 |
| Bat-CoV HKU8 | – | 0.40/0.42 | 74/81 | 56/61 | 56/62 | 76/81 | 84/92 | – |
| Group 2 | ||||||||
| CoV-HKU1 | 0.32 | 0.32/0.33 | 55/53 | 67/66 | 68/66 | 57/56 | 57/54 | 52/54 |
| HCoV-OC43 | 0.37 | 0.36/0.38 | 56/54 | 68/67 | 68/67 | 57/57 | 56/55 | 53/55 |
| MHV | 0.42 | 0.39/0.39 | 56/55 | 68/67 | 68/67 | 57/57 | 57/56 | 53/55 |
| BCoV | 0.37 | 0.36/0.38 | 56/54 | 68/67 | 68/67 | 58/57 | 57/56 | 53/55 |
| SARS-CoV | 0.41 | 0.39/0.41 | 59/61 | 71/70 | 71/71 | 60/61 | 58/60 | 55/61 |
| Bat-SARS-CoV HKU3 (Lau et al., 2005) | 0.41 | 0.40/0.40 | 59/61 | 71/70 | 71/71 | 60/61 | 58/60 | 59/61 |
| Bat-SARS-CoV (Li et al., 2005) | 0.41 | 0.40/0.41 | 59/61 | 71/70 | 71/71 | 60/61 | 58/60 | 59/61 |
| Bat-CoV HKU4 | – | 0.37/0.38 | 58/61 | – | 92/93 | 59/63 | 59/62 | 56/61 |
| Bat-CoV HKU5 | – | 0.41/0.44 | 58/62 | 92/93 | – | 59/63 | 59/62 | 56/62 |
| Group 3 | ||||||||
| IBV | 0.38 | 0.38/0.37 | 57/55 | 60/57 | 59/58 | 56/57 | 57/55 | 54/56 |
a
HCoV-229E, human coronavirus 229E; PEDV, porcine epidemic diarrhea virus; TGEV, porcine transmissible gastroenteritis virus; FeCoV, feline coronavirus; HCoV-NL63, human coronavirus NL63; HCoV-OC43, human coronavirus OC43; MHV, murine hepatitis virus; BCoV, bovine coronavirus; CoV-HKU1, coronavirus HKU1; SARS-CoV, SARS coronavirus; bat-SARS-CoV, SARS coronavirus-like virus found in bats; IBV, infectious bronchitis virus.