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Schematic showing the suggested membrane insertion of a monomer of (a) the 1-MSD and (b) the 3-MSD forms of gp41 of HIV-1 clades A to D. The positions of the two potential tyrosine-sorting signals and the minor ectodomain containing the Kennedy sequence are shown. The major ectodomain at the N-terminus of gp41 and gp120 have been omitted. The distance shown in (b) between MSD 2 and 3 (reading from left to right) is conjectural.
