Table 2.

Comparison of the preferences of AP complexes for cellular tyrosine-dependent sorting signals^a with the consensus sequence for the first and second potential tyrosine-dependent sorting signals of the gp41 of HIV-1 clades A to D

Position (relative to Y)	AP-1 preferences	AP-2 preferences	AP-3 preferences	HIV-1 tyrosine-dependent sorting signal sequences
				First	Second
− 3	R	G	R	R	L
− 2	S	F	Np	Q	F
− 1	L/D	P	D/E/G	G	S
0 (Y)	Y	Y	Y	Y	Y
1 (x)	Np	Np	E	S	H
2 (x)	P	P/R	P	P	R
3 (φ)	L	L	I	L	L

Np, no preference known at this position; x, any amino acid residue; φ, a bulky hydrophobic residue.

^aBoll et al. (1996), Heilker et al. (1999), Höning et al. (1996), Ohno et al., 1995, Ohno et al., 1996, Ohno et al., 1998, Ooi et al. (1997), Owen and Evans (1998), Simpson et al. (1997), Stephens and Banting (1998), Stepp et al. (1997).