Table 7.
Codon-based Z-test for positive selectiona in the spike gene.
| TCoV/TX-1038/98 | TCoV/IN-517/94 | TCoV/TX-GL/01 | TCoV/VA-74/03 | TCoV/MG10/07 | TCoV/MN-ATCC/69 | TCoV/IN-540/94 | |
|---|---|---|---|---|---|---|---|
| TCoV/TX-1038/98 | – | − 0624 | − 3.299 | 2.784 | 2.674 | − 3.690 | − 2.036 |
| TCoV/IN-517/94 | 1.000 | – | − 2.862 | − 2.176 | − 2.258 | − 4.532 | − 2.842 |
| TCoV/TX-GL/01 | 1.000 | 1.000 | – | − 2.791 | − 2.850 | − 4.635 | − 2.847 |
| TCoV/VA-74/03 | 0.003 | 1.000 | 1.000 | – | 1.032 | − 3.786 | − 2.891 |
| TCoV/MG10/07 | 0.004 | 1.000 | 1.000 | 0.152 | – | − 3.743 | − 2.953 |
| TCoV/MN-ATCC/69 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | – | − 4.744 |
| TCoV/IN-540/94 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | – |
a
The probabilities (P) of rejecting the null hypothesis of strict neutrality (dN = dS) in favor of the alternative hypothesis (dN > dS) is shown below the diagonal. Values of P < 0.05 are considered significant. The test statistic values shown above the diagonal are the numbers of synonymous dS and non-synonymous dN substitutions per site, respectively. The variance of the difference was computed using the bootstrap method (1000 replicates).