Fig. 3.

Cellular entry mediated by Marburg virus glycoprotein is largely cathepsin-independent. 293T target cells were preincubated with the indicated concentrations of protease inhibitors leupeptin, AEBSF and CA074Me. Subsequently, cells were infected with pseudotypes bearing the indicated GPs, normalized for equal infectivity and luciferase activity in cell lysates was measured at 72 h post infection. The results ± SD of a representative experiment performed in triplicates are shown and were confirmed in at least two separate experiments.