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. 2012 Oct 16;435(2):372–384. doi: 10.1016/j.virol.2012.09.013

Fig. 5.

Fig. 5

(A) Lung section from a Group 2 pig inoculated with rJXwn06. Severe diffuse histiocytic and necrotizing interstitial pneumonia with a suppurative bronchiolitis (asterisks). Alveolar lumina were filled with alveolar macrophages, neutrophils and necrotic debris; clumps of chromatin (arrows) were present. Alveolar septa were thickened by histiocytes and vessels were cuffed by perivascular macrophages, lymphocytes and plasma cells. 100x. (B) Lung section from a Group 2 HP-PRRSV inoculated pig. Positive cytoplasmic PRRSV labeling was seen in alveolar macrophages, interstitial macrophages and macrophages present in the bronchiole lumen. 200x, Immunoperoxidase-DAB, hematoxylin counterstain. (C) Lung section from a Group 4 pig inoculated with strain VR-2332. Moderate multifocal histiocytic interstitial pneumonia. Alveolar septa were thickened by histiocytes and alveolar lumina contained alveolar macrophages and neutrophils. 100x, HE. (D) Lung section from a Group 4 strain VR-2332 inoculated pig. Positive cytoplasmic PRRSV labeling was seen in alveolar macrophages and interstitial macrophages. 200x, Immunoperoxidase-DAB, hematoxylin counterstain.