Table 1.
| Groupa | mAb | Binding region | S binding Inhibitionb | IC50 (μg/ml)c |
|---|---|---|---|---|
| 1A1 | 4E2 | RBD | Y | 5.31 |
| 1A1 | 4G2 | RBD | Y | 4.78 |
| 1A1 | 6C1 | RBD | Y | 4.81 |
| 1B1 | 3A7 | RBD | Y | 1.17 |
| 1B1 | 5A7 | RBD | Y | 4.94 |
| 1B1 | 5D3 | RBD | Y | 1.9 |
| 1B1 | 5D6 | RBD | Y | 3.17 |
| 1B1 | 6B8 | RBD | Y | 3.27 |
| 1B2 | 4A10 | RBD | Y | 6.12 |
| 1B2 | 5A5 | RBD | Y | 6.79 |
| 1B2 | 3F3 | RBD | Y | 2.31 |
| 1B2 | 6B5 | RBD | Y | 2.02 |
| 1B2 | 6C2 | RBD | Y | 3.53 |
| 1B3 | 5E4 | RBD | Y | 2.13 |
| 1B4 | 3C7 | RBD | Y | 4.28 |
| 1B4 | 6B1 | RBD | Y | 4.08 |
| 1D | 3H12 | RBD | Y | 3.71 |
| 1Ed | 1B5 | RBD | Y | 2.84 |
| 2B1 | 4D4 | 12–261 | N | N/A |
a
mAb group determined previously based on ELISA reactivity and immunoglobulin sequence data.
b
Inhibition of binding of recombinant S protein 12–510-Fc to the surface of target VeroE6 cells.
c
IC50 values determined from inhibition curve of the mAb.
d
mAb 1B5 was previously designated in group 2B2, upon further analysis of the purified mAb 1B5 it was determined to be RBD specific mAb with a unique CDR3 sequence and added to group 1 with designation group 1E.