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. 2019 Aug 9;536:110–118. doi: 10.1016/j.virol.2019.08.006

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© 2019 Elsevier Inc.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 4 — EM observation of in vitro SeACoV infection in comparison with PEDV infection. Vero cells were infected with SeACoV (A) or PEDV (B) or mock-infected (C) at 24 hpi. CoV-induced cellular ultrastructural changes, including double-membrane vesicles (DMVs) (arrowheads), large virion-containing vacuoles (LVCVs) (black arrows), and phagosome-like vacuoles or lysosomes containing endoplasmic reticulum and other vesicles (white arrows) were visible in the cytoplasm. N: Nucleus. M: mitochondria. Bar = 0.5 μm.