Table 1.
Summary of major pathologic reports on SARS
| Serial no. | First author/countries | No. of patients | Organs reported | Major pathologic findings | Reference |
|---|---|---|---|---|---|
| 1 | Nicholls/HK, China | 6 | Mainly lung | DAD (Fig. 1A-D), giant cells, enlarged pneumocytes, prominent macrophages (Fig. 1C and 1E1), white pulp atrophy of spleen (Fig. 2C), hemophagocytosis (Fig. 2A and B). | [6] |
| 2 | Tse/HK, China | 7 | Lung | DAD, multinucleated pneumocytes, BOOP-like pattern of organization (Fig. 1C and D). | [7] |
| 3 | Cheung/HK, China | 10 | Lung | DAD with organization and fibrosis, no specific histology | [8] |
| 4 | Lang/China | 3 | General autopsy | DAD, hemorrhagic necrosis in lymph node and spleen, lymphocyte depletion in spleen | [9] |
| 5 | Ding/China | 3 | General autopsy | DAD, necrosis in splenic lymphoid tissue and lymph node, systemic vasculitis | [10] |
| 6 | Hsiao/Taiwan, China | 4 | Lung | DAD, no specific histology, DAD absent in early stage | [11] |
| 7 | Franks/Singapore Chongs/ Singapore | 8 | Lung | DAD, acute phase in ≤10 days, organizing phase in >10 days, multinucleated pneumocyte and macrophages | [12], [13] |
| 8 | Hwang/Canada | 20 | Lung | DAD in 8, acute fibrinous and organizing pneumonia in 6, mixed pattern in 6, multinucleated giant cells, fibrin thrombi | [14] |
| 9 | Chau/HK, China | 3 | Liver | accumulation of mitosis and apoptosis, ballooning hepatocytes, lobular inflammation (Fig. 2F). | [15] |
| 10 | Leung/HK, China | 6 | Intestinal tract | Minimal architectural disruption but with active viral replication in small and large intestine | [16] |
| 11 | Leung/HK, China | 8 | Skeletal muscle | Spectrum of myopathic changes, focal fiber necrosis common (Fig. 2D). | [17] |
| 12 | Chu/HK, China | 7 | Kidney | Acute tubular necrosis (Fig. 2E), normal glomeruli | [18] |
| 13 | Wong/HK, China | 4 | Hematolymphoid | Atrophic white pulp in spleen, active bone marrow, reactive hemophagocytosis not seen | [19] |