Table 2.

Summary of pathologic reports on H5N1

Case	Sex/age	Year/countries	Duration of disease (d)	Major pathologic findings	Reference
1	F/13	1997/Hong Kong	30	Organizing DAD with interstitial fibrosis (Fig. 3D-F), reactive hemophagocytic syndrome, lymphoid depletion (Fig. 4C), hepatic centrilobular necrosis, acute renal tubular necrosis, microglial nodules with demyelination in cerebral white matter (Fig. 4E and F).	[26]
2	F/25	1997/Hong Kong	30	Similar to above except for normal brain, presence of extramedullary hematopoiesis and focal necrosis in lymph node	[26]
3	M/33	2003/Hong Kong	10	Acute DAD (Fig. 3A-C), reactive hemophagocytic syndrome (Fig. 4A and B), activated lymphoid cells in reticuloendothelial system, lymphoid depletion, skeletal muscle fiber necrosis (Fig. 4D), acute renal tubular necrosis, normal brain	[4]
4	F/26	2004/Thailand	10	DAD, interstitial pneumonia, cholestasis, hemophagocytic activity in liver, lymphoid depletion in spleen	[27]
5	M/6	2004/Thailand	17	Consolidated lungs with focal hemorrhage, DAD, interstitial lymphoplasmacytic infiltrate, bronchiolitis, histiocytosis in lymphoid system but no hemophagocytosis, reactive hepatitis, small foci of necrosis in brain	[28], [29]
6, 7, 8	Not specified	2004/Thailand	Not specified	Lung and spleen examined only, DAD with hyaline membrane, reactive fibroblasts and hemorrhage, atypical lymphocytes in spleen.	[30]

NOTE. Fig. 3, Fig. 4 are new photomicrographs showing pathologic changes in case 1 and 3 examined by the authors.