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A, SARS-CoV and CD68 antigens in alveolar macrophage. Red stain, SARS-CoV; brown stain, CD68 (double-stain IHC with immunoalkaline phosphatase and peroxidase polymer). B, SARS-CoV antigens in intraalveolar necrotic debris. C and D, Extracellular virions were often associated with fibrin within the alveolar space. C inset, Higher magnification of area at arrow. Bar size indicated in micrometers or nanometers.
