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. 2018 Feb 16;100:163–188. doi: 10.1016/bs.aivir.2018.01.001

Fig. 2.

Fig. 2

Genome characteristics and mutation patterns of HCoV-229E and related viruses from animals. (A) Maximum-likelihood phylogeny of complete genomes of representative HCoV-229E-related coronaviruses from humans, camelids, and bats. Filled circles at nodes indicate bootstrap supports of 100% (200 replicates). HCoV-NL63 GenBank (accession no. NC_005831) was used as an outgroup (branch truncated). (B) Genomic organization of 229E-related coronaviruses. Regions with deletions are given in red. (C and D) Deletion patterns in ORF 8 homologs of 229E-related coronaviruses regions with deletions are given in red (numbered I–IV). Asterisks represent triplets that would act as in-frame stop codons; arrows represent possible start codons.

Figure was adapted from Corman, V.M., Eckerle, I., Memish, Z.A., Liljander, A.M., Dijkman, R., Jonsdottir, H., Juma Ngeiywa, K.J., Kamau, E., Younan, M., Al Masri, M., Assiri, A., Gluecks, I., Musa, B.E., Meyer, B., Muller, M.A., Hilali, M., Bornstein, S., Wernery, U., Thiel, V., Jores, J., Drexler, J.F., Drosten, C. 2016. Link of a ubiquitous human coronavirus to dromedary camels, Proc. Natl. Acad. Sci. U. S. A., 113, 9864–9869.