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. 2018 Dec 6;527:169–179. doi: 10.1016/j.virol.2018.11.014

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© 2018 Elsevier Inc.

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Fig. 6 — The functional associated analysis of the parent genes for selected circRNAs A) The STRING analysis shows these parent genes of selected circRNAs are functional associated. These genes with their associated partners are mainly involved in the process of posttranslational modification of proteins by sumoylation, transport of proteins between the endoplasmic reticulum and Golgi compartments, and the regulation of cell cycle. CAD and CTNNB1 served as the key nodes in the interaction network. B) The expression levels of CAD and CTNNB1 at different time points post PEDV infection were measured real-time PCR analysis. C) The siRNA candidates were transfected into IPEC-J2 cells to knockdown the expressions of CAD2 and CTNNB1–2. D) The CAD and CTNNB1 in IPEC-J2 cells were knocked-down by specific siRNAs. The kinetics of PEDV replication in these cells was measured by TCID₅₀ assay. Scramble siRNA was served as negative control. E) The ratios of PEDV genome copies in siCAD and siCTNNB1 cells were normalized by that in NC cells.