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. 2017 Dec 14;517:188–198. doi: 10.1016/j.virol.2017.11.024

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© 2017 Elsevier Inc.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 1 — Changes in Toll Like receptor (TLRs) mRNA expression induced by porcine epidemic diarrhea virus (PEDV) non S-INDEL and PEDV S-INDEL strains in intestinal mucosa (A-F). Ten pigs in each group were infected with PEDV non S-INDEL, PEDV S-INDEL or media (negative control) and five pigs from each group were necropsied at 3 and 7 days post-infection (dpi). The mRNA levels of TLR2 (A), TLR 3 (B), TLR4 (C), TLR7 (D), TLR8 (E), and TLR9 (F) at the intestinal mucosa was determined individually in each animal by SYBR- green qRT-PCR. All samples were tested in triplicate and the results are expressed as fold changes relative to the control animals Data are presented as means ± standard errors. Significant difference between PEDV S-INDEL PEDV non S-INDEL and control group are expressed with their p values. *p < 0.05; **p < 0.01, ***p < 0.001.