Table 4.

Impact of a) IPT and b) ART on TB or death

	CD4≤350 N=2,138				CD4>350 N=1,976
	TB or death	Person-years	IR per 100 pys (95% CI)	IRR (95% CI)	TB or death	Person-years	IR per 100 pys (95% CI)	IRR (95% CI)
a) IPT
TST-negative / no IPT	163	5,410	3.01 (2.58–3.51)	REF	73	4,894	1.49 (1.19–1.88)	REF
TST-negative / IPT	3	137	2.19 (0.71–6.78)	0.76 (0.24–2.39)	2	127	1.57 (0.39–6.29)	1.22 (0.30–4.98)
TST-positive / no IPT	29	183	15.89 (11.04–22.87)	REF	23	268	8.57 (5.70–12.90)	REF
TST-positive / IPT	20	923	2.17 (1.40–3.36)	0.15 (0.08–0.26)	24	1,385	1.73 (1.16–2.59)	0.21 (0.13–0.37)
TST-unknown / no IPT	156	3,361	4.64 (3.97–5.43)	REF	64	3,054	2.10 (1.64–2.68)	REF
TST-unknown / IPT	0	34	0	—	1	37	2.71 (0.38–19.27)	1.46 (0.21–10.10)
b) ART
TST-negative / no ART	11	264	4.16 (2.30–7.51)	REF	47	2,758	1.70 (1.28–2.27)	REF
TST-negative / ART	146	4,890	2.99 (2.54–3.51)	0.70 (0.38–1.30)	28	1,892	1.48 (1.02–2.14)	0.77 (0.49–1.22)
TST-positive / no ART	10	53	18.95 (10.19–35.21)	REF	33	1,053	3.13 (2.23–4.41)	REF
TST-positive / ART	39	1,005	3.88 (2.83–5.31)	0.22 (0.11–0.46)	14	510	2.75 (1.63–4.64)	0.80 (0.41–1.57)
TST-unknown / no ART	34	1,445	2.35 (1.68–3.29)	REF	38	2,619	1.45 (1.06–1.99)	REF
TST-unknown / ART	131	2,391	5.48 (4.62–6.50)	2.31 (1.59–3.36)	27	934	2.89 (1.98–4.22)	1.84 (1.14–2.97)

Abbreviations: IPT, isoniazid preventive therapy; ART, antiretroviral therapy; TB, tuberculosis; IR, incidence rate; CI, confidence interval; IRR, incidence rate ratio; TST, tuberculin skin test

TST, IPT, and ART time-dependent; IRRs adjusted for sex and age at enrollment