Table 2.

A. Characteristics and echocardiographic data in young adult wild-type and Tbx5^R264K/R264K mice. B. Characteristics and echocardiographic data of isoproterenol stimulation in young adult wild-type and Tbx5^R264K/R264K mice.

A
	Wild-type		Tbx5R264K/R264K
	(n = 5)		(n = 7)
male	2		3
BW (g)	22.5±1.9		22.9±1.5
HR (/min)	413.2±12.7		431.2±34.2
LVDd (mm)	3.54±0.16		3.89±0.21*
LVDs (mm)	2.14±0.23		2.56±0.17**
AWD (mm)	0.68±0.12		0.56±0.05*
PWD (mm)	0.82±0.07		0.66±0.1*
FS (%)	39.6±5.4		34.2±1.7*
E (cm/s)	51.9±7.0		61.2±14.1
A (cm/s)	31.2±6.3		34.1±5.0
HW (mg)	115.4±10.2		132.9±8.9*
HW/BW	5.12±0.08		5.80±0.32**
B
	Wild-type		Tbx5R264K/R264K
	Vehicle (n = 4)	Isoproterenol (n = 4)	Vehicle (n = 4)	Isoproterenol (n = 4)
male	2	2	2	2
BW (g)	24.5±1.0	24.7±0.9	22.8±1.5	23.4±0.8
HR (/min)	430.7±9.2	429.6±15.1	443.7±14.4	444.7±14.1
LVDd (mm)	3.63±0.22	3.83±0.11	4.10±0.25	4.18±0.09§
LVDs (mm)	2.33±0.17	2.66±0.11	2.90±0.2	3.18±0.09§
AWD (mm)	0.85±0.06	0.90±0.06	0.63±0.05†	0.73±0.03§
PWD (mm)	0.95±0.09	0.88±0.05	0.58±0.05††	0.7±0.04§
FS (%)	36.0±1.1	30.4±1.7*	29.4±0.8††	24.0±0.5‡§§
E (cm/s)	55.8±2.7	47.5±1.4*	57.5±3.7	48.8±2.5
A (cm/s)	35.8±5.8	27.5±3.9	33.1±3.5	34.9±3.6
HW (mg)	117.0±5.5	119.0±4.3	116.3±5.9	125.5±3.9
HW/BW	4.45±0.11	4.82±0.18	5.11±0.10††	5.37±0.04§

BW: body weight, HR: heart rate, LVDd: left ventricle diameter at end diastole, LVDs: left ventricle diameter at end systole, AWD: left ventricular anterior wall thickness at end diastole, PWD: left ventricular posterior wall thickness at end diastole, FS: fractional shortening, E: trans-mitral early wave, A: trans-mitral atrial wave, HW: heart weight, P value *<0.05, versus wild-type vehicle,

†<0.05,

††<0.01, versus wild-type vehicle,

‡<0.05 versus young adult TBX5^R264K/R264K vehicle, and.

§<0.05,

§§<0.01, versus wild-type isoproterenol. P value.

*<0.05,

**<0.01.