Table 1. Genotype differences on alcohol intake in 4-day drinking-in-the-dark (DID) model (A) and on alcohol intake and alcohol preference in chronic (3 weeks) intermittent access excessive drinking model (B) between male nPE1^+/+ and nPE1^−/− mice.

(A) in DID model, alcohol was presented 3 hours after the beginning of dark cycle, and alcohol intake was recorded after 4 hours of alcohol access for 4 days in the nPE1^+/+ and nPE1^−/− mice. Genotype difference: **p<0.01 vs. nPE1^+/+ at the same day; Day difference: ++p<0.01 vs. the same genotype on day 1 by 2-way ANOVA with Newman-Keuls post-hoc tests (n=6 for each group); (B) in IA model, mice exposed to the 2-bottle “alcohol (15%) vs. water” choice regimen every other day for 3 weeks. Data are presented after 4, 8 and 24 hours of alcohol access in the session 1 and in the session 10 during 3 weeks of chronic IA excessive alcohol drinking. Genotype difference: *p<0.05 or **p<0.01 vs. nPE1^+/+ at the same time point in the same session; Session difference: +p<0.05 or ++p<0.01 vs. the same genotype at the same time point in the session 1 by 3-way ANOVA with Newman-Keuls post-hoc tests (n=6 for each group). Data presented as mean ± SEM.

A. Alcohol intake (g/kg) on day 1 and day 4 in DID model.
	Day 1		Day 4
Genotype	nPE1+/+	nPE1−/−	nPE1+/+	nPE1−/−
Alcohol intake	4.1 ± 0.35	1.1 ± 0.38 **	5.8 ± 0.35 ++	3.9 ± 0.63 ** ++

B. Alcohol intake (g/kg) and preference ratio in session 1 and session 10 in chronic IA model.
		Session 1		Session 10
		nPE1+/+	nPE1−/−	nPE1+/+	nPE1−/−
Alcohol Intake g/kg	4h	3.9 ± 0.43	1.9 ± 0.28	5.6 ± 0.59 +	2.7 ± 0.43
	8h	5.3 ± 0.51	2.3 ± 0.34 *	9.7 ± 0.59	4.5 ± 0.74 **
	24h	13 ± 2.3	4.9 ± 0.90 **	19 ± 2.0 ++	9.5 ± 1.2 ** ++
Alcohol preference ratio	4h	0.59 ± 0.10	0.38 ± 0.07 *	0.86 ± 0.02 +	0.63 ± 0.05 * ++
	8h	0.67 ± 0.05	0.34 ± 0.13 **	0.81 ± 0.04	0.60 ± 0.07 ++
	24h	0.54 ±0.06	0.38 ± 0.06 **	0.73 ± 0.04	0.61 ± 0.06 +