Table 5.

Schematic diagram of genetically determined differences between nPE1^+/+ and nPE1^−/− male mice and effects of acute (1-day) withdrawal from chronic (4-week) excessive alcohol drinking on nuclear transcript levels of opioid genes (A) and stress genes (B) in the hypothalamus. “Increase”, “Decrease” or “No change [nc]” indicate the direction of changes from baseline in nPE1^+/+ water group.

A. Opioid genes
Genotype	nPE1+/+		nPE1−/−
Treatment	water	alcohol	water	alcohol
Pomc	baseline	increase	decrease	nc
Oprm1	baseline	increase	increase	increase
Pdyn	baseline	nc	decrease	nc
Oprk1	baseline	nc	increase	nc
Penk	baseline	nc	nc	nc
Oprd1	baseline	nc	decrease	nc
Pnoc	baseline	nc	decrease	nc
Oprl1	baseline	nc	decrease	nc
B. Stress genes
Genotype	nPE1+/+		nPE1−/−
Treatment	water	alcohol	water	alcohol
Oxt	baseline	decrease	decrease	nc
Oxtr	baseline	nc	decrease	nc
Avp	baseline	nc	decrease	nc
Avpi1	baseline	decrease	nc	nc
Avpr1a	baseline	nc	nc	nc
Nr3c1	baseline	decrease	increase	nc
Nr3c2	baseline	nc	nc	nc
Fkbp5	baseline	nc	nc	nc
Crh	baseline	nc	nc	nc
Crhbp	baseline	nc	nc	nc
Crhr1	baseline	nc	nc	nc
Crhr2	baseline	nc	nc	nc