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. 2020 Apr 1;15(4):e0228121. doi: 10.1371/journal.pone.0228121

Fig 4. Distal C-terminus phosphorylation sites can deactivate melanopsin, to varying degrees.

Fig 4

(A) Representative calcium imaging of phosphonull mutants with twelve phosphorylation sites mutated from alanine residues to serine or threonine residues, specifically, P-II and P-III. Error bars represent the S.D. (B) Representative calcium imaging of a phosphonull mutant, analyzing P-II and P-IV. Error bars represent the S.D. (C) Quantification of deactivation rates of melanopsin mutants analyzed in (A) and (B). Error bars in (C) represent the S.E.M. of three independent transfections. P<0.05, 0.01, 0.001, 0.0001 correspond to *, **, ***, ****, respectively.