Table 1. Potency of candidate compounds in various parasite systems.
| Parasite | Anisomycin | Prodigiosin | Obatoclax | Nithiamide | Control |
|---|---|---|---|---|---|
| Entamoeba | 0.7 | 0.7 | 0.5 | 5 | Metronidazole (8.9μM) |
| Giardia | 18.5 | 3.8 | 0.9 | 2.6 | Metronidazole (6.4μM) |
| Naegleria | 4.7 | 6.4 | 3.6 | no activity | Amphotericin (0.2μM) |
| Acanthamoeba | no activity | 2.2 | 0.5 | no activity | PHMB (9.8μM) |
| Balamuthia (trophozoites) | no activity | 4 | 1.5 | no activity | Nitroxoline (2.8μM) |
| Balamuthia (cysts) | no activity | 3.8 | 1.7 | no activity | Nitroxoline (15.5 μM) |
| Plasmodium | 0.1 | nt* | nt* | no activity | Atovaquone (23nM) |
| Cryptosporidium | 0.08 | 0.09 | 2.1 | no activity | Nitazoxanide (2.07μM) |
| Schistosoma (juvenile) | no activity | 1 | 0.6 | no activity | Praziquantel (4.7μM) |
| T. brucei | 0.10 | 0.03 | 0.04 | 3.6 | Pentamidine (0.11μM) |
The EC50 values for anisomycin, prodigiosin, obatoclax and nithiamide for each parasite tested are shown. All concentrations are micromolar. Results for control compounds are from the same experiment except as indicated: metronidazole (Entamoeba) [6], nitroxoline (Balamuthia) [21], Atovaquone (Plasmodium) [22]; praziquantel (juvenile Schistosoma) [23]. * indicates that compound was not tested as it was incompatible with the assay.