Table 1. Antimicrobial and resistance modulatory activity of (-)-α-pinene with antibiotics ciprofloxacin and erythromycin in 57 Campylobacter jejuni strains from chicken meat (strain code, CB), turkey meat (strain code, CT), human feces (strain codes F, X) and the reference strain NCTC 11168.
Strain | (-)-α-Pinene | Ciprofloxacin | Erythromycin | ||||
---|---|---|---|---|---|---|---|
code | MIC (mg/L) | MIC (mg/L) | Fold | MIC (mg/L) | Fold | ||
Alone | Alone | Plus (-)-α-pinenea | changeb | Alone | Plus (-)-α-pinenea | changeb | |
CB1:6 | 1000 | 16 | <0.125 | >128 | 0.5 | <0.002 | >256 |
CB1:14 | 1000 | 16 | <0.125 | >128 | 0.5 | <0.002 | >256 |
CB1:18 | 1000 | 16 | <0.125 | >128 | 0.5 | 0.125 | 4 |
CB2:6 | 2000 | 64 | 16 | 4 | 0.5 | 0.06 | 8 |
CB2:8 | 2000 | 64 | 32 | 2 | 0.5 | 0.25 | 2 |
CB2:11 | 1000 | 8 | 4 | 2 | 0.5 | 0.25 | 2 |
CB3:1 | 2000 | 0.125 | 0.06 | 2 | 0.25 | 0.06 | 4 |
CB3:5 | 2000 | 0.25 | 0.06 | 4 | 0.5 | 0.25 | 2 |
CB 4:21 | 1000 | 0.06 | 0.03 | 2 | 0.06 | <0.002 | >32 |
CB 4:22 | 2000 | 0.125 | 0.001 | 128 | 0.06 | 0.002 | 32 |
CB 6:8 | 2000 | 0.06 | 0.008 | 8 | 0.125 | <0.002 | >64 |
CB 6:9 | 2000 | 0.06 | 0.03 | 2 | 0.125 | 0.06 | 2 |
CB 6:26 | 2000 | 0.06 | 0.03 | 2 | 0.25 | 0.125 | 2 |
CB 7:15 | 1000 | 8 | <0.06 | >128 | 0.25 | <0.002 | >128 |
CB 7:21 | 2000 | 8 | 1 | 8 | 0.125 | <0.002 | >64 |
CB 8:14 | 2000 | 0.06 | 0.001 | 64 | 0.125 | 0.002 | 64 |
CB 8:15 | 1000 | 0.06 | 0.001 | 64 | 0.5 | <0.002 | >256 |
CT 1:1 | 2000 | 16 | 1 | 16 | 0.5 | 0.03 | 16 |
CT 1:9 | 1000 | 16 | 2 | 8 | 0.5 | 0.06 | 8 |
CT 2:2 | 2000 | 16 | <0.06 | >256 | 256 | <1 | >256 |
CT 3:5 | 2000 | 0.06 | <0.001 | >64 | 0.03 | <0.002 | 16 |
CT3:11 | 500 | 4 | <0.06 | >64 | - | - | - |
CT3:19 | 2000 | 16 | <0.06 | >256 | 512 | <1 | >512 |
CT4:4 | 2000 | 16 | 8 | 2 | 128 | 64 | 2 |
CT4:14 | 2000 | 8 | 8 | 1 | 128 | 64 | 2 |
CT5:2 | 2000 | 16 | 4 | 4 | 256 | 256 | 1 |
CT5:8 | 2000 | 8 | 2 | 4 | 256 | 16 | 16 |
CT5:10 | 2000 | 16 | <0.06 | >256 | 256 | <1 | >256 |
CT5:12 | 2000 | 16 | 4 | 4 | 256 | 32 | 8 |
CT5:18 | 2000 | 16 | 4 | 4 | 256 | 64 | 4 |
CT 6:18 | 2000 | 8 | 0.5 | 16 | 128 | <1 | >128 |
CT 6:8 | 2000 | 16 | 2 | 8 | 256 | <1 | >256 |
CT 6:16 | 2000 | 0.03 | <0.001 | >32 | 128 | <1 | >128 |
CT 7:2 | 2000 | 0.03 | <0.001 | >32 | 0.06 | 0.002 | 32 |
CT 8: 28 | 2000 | 8 | 1 | 8 | 0.25 | <0.008 | >32 |
CT 8:29 | >2000 | 4 | <0.06 | >64 | 64 | 8 | 8 |
CT 8:22 | 2000 | 4 | 0.5 | 8 | 0.5 | 0.5 | 1 |
CT 9:14 | 2000 | 0.25 | <0.002 | >128 | 2 | <0.008 | >256 |
CT 10:18 | 1000 | 0.06 | <0.002 | >32 | 0.25 | <0.008 | >32 |
CT 9:21 | 1000 | 0.125 | <0.002 | >64 | 2 | <0.008 | >256 |
F6501 | >2000 | 0.125 | 0.06 | 2 | 0.25 | 0.125 | 2 |
H2958 | 2000 | 0.125 | 0.03 | 4 | 0.5 | 0.25 | 2 |
M63885 | 2000 | 0.25 | <0.002 | >128 | 0.5 | <0.008 | >64 |
T59822 | 2000 | 0.125 | 0.016 | 8 | 0.25 | 0.06 | 4 |
W14861 | >2000 | 0.25 | 0.25 | 1 | 2 | 2 | 1 |
X60179 | 2000 | 8 | <0.06 | >128 | 0.25 | <0.002 | >128 |
F15871 | >2000 | 0.125 | 0.06 | 2 | 1 | 0.5 | 2 |
W11805 | 2000 | 0.06 | 0.031 | 2 | 0.25 | 0.06 | 4 |
M402 | >2000 | 0.06 | 0.031 | 2 | 1 | 0.5 | 2 |
W28752 | 2000 | 0.06 | 0.008 | 8 | 0.5 | <0.002 | >256 |
M33323 | 2000 | 0.06 | 0.06 | 1 | 0.25 | 0.25 | 1 |
W64861 | 2000 | 0.125 | 0.06 | 2 | 0.25 | 0.25 | 1 |
M76297 | 2000 | 0.06 | 0.03 | 2 | 0.25 | 0.125 | 2 |
E46972 | >2000 | 1 | <0.002 | >512 | 0.25 | <0.008 | >32 |
M36292 | 2000 | 0.06 | <0.002 | >32 | 0.25 | <0.008 | >32 |
X7199 | >2000 | 16 | 16 | 1 | 0.25 | 0.125 | >32 |
NCTC 11168 | 2000 | 0.06 | 0.03 | 2 | 0.25 | 0.06 | 4 |
MIC90c | 2000 | 16 | 4 | 4 | 256 | 16 | 16 |
MIC50d | 2000 | 0.25 | 0.06 | 4 | 0.5 | 0.06 | 8 |