Fig. 5.

Corticosteroid (CS) treatment significantly reduces oligodendrocyte‐mediated remyelination of EB‐induced lesions in the spinal cord at 1 month. Treatment groups consisted of injection of high‐dose MPS with and without subsequent PRED taper, in order to mimic current CS treatment regimens used clinically to treat acute relapses in MS. (A) Extensive oligodendrocyte and Schwann cell‐mediated remyelination in saline‐injected control rats. (B, C) Reduced oligodendrocyte remyelination in CS‐treated rats with Schwann cell remyelination unaffected. Oligodendrocyte remyelination is indicated with arrows. MPS, methylprednisolone, PRED, prednisone. Modified with permission from Chari et al. (2006a).