Table 1.
The human ADAMs
| Gene | Other aliases | Accession number | Location | Proteolytic activity? | Present in Mus musculus | Inhibition by TIMPs | Major sites of expression in human tissues |
|---|---|---|---|---|---|---|---|
| ADAM1 | Fertilin alpha, FTNAP, Ftna, PH-30a | NG_001216 | 12q24.13 | Pseudogene | Yes (NM_172126, NM_172125) | – | – |
| ADAM2 | Fertilin beta, CRYN1, CRYN2, FTNB, PH-30b, PH30 | NM_001464 | 8p11.2 | No | Yes (NM_009618) | No study | Testis |
| ADAM3 | CYRN1, tMDCI | NR_001569 | 8p21-p12 | Pseudogene | Yes (NM_009619) | – | – |
| ADAM5 | TMDCII | NR_001448 | 8p11.23 | Pseudogene | Yes (NM_007401) | – | – |
| ADAM6 | t MDCIV; C14orf96 | NR_002224 | 14q32.33 | Probably pseudogene | Yes (NM_174885) | – | – |
| ADAM7 | EAPI, GP-83 | NM_003817 | 8p21.2 | No | Yes (NM_007402) | – | Testis, erythrocytes |
| ADAM8 | CD156, MGC134985, MS2 | NM_001109 | 10q26.3 | Yes | Yes (NM_007403) | None | Bone marrow lymphoid/ myeloid cells, lymphatic system, haematopoietic stem cells, peripheral blood lymphoid/myeloid cells |
| ADAM9 | KIAA0021, MCMP, MDC9, Mltng, meltrin gamma | v1 NM_003816 | 8p11.23 | Yes | Yes (NM_007404) | None | Mesenchymal stem cells, placenta, pancreas, adult stem cells, adipose tissue |
| v2 NM_001005845 | |||||||
| ADAM10 | CD156c, HsT18717, MADM, kuz | NM_001110 | 15q22 | Yes | Yes (NM_007399) | TIMP-1 TIMP-3 | Mesenchymal stem cells, placenta, blood myeloid cells, bladder, bone marrow myeloid cells |
| ADAM11 | MDC | NM_002390 | 17q21.3 | No | Yes (NM_009613, NM_001110778) | – | Erythrocytes, central and peripheral nervous systems, liver and biliary system, salivary gland |
| ADAM12 | RP11-295J3.5, MCMP, MCMPMltna, MLTN, MLTNA, Meltrin alpha | v1 NM_003474 | 10q26.3 | Yes | Yes (NM_007400) | TIMP-2 | Placenta, mesenchymal stem cells, adult stem cells |
| v2 NM_021641 | TIMP-3 | ||||||
| ADAM15 | MDC15, Metargidin | v1 NM_207191 | 1q21.3 | Yes | Yes (NM_001037722, NM_009614) | No study | Widespread (highest in mesenchymal stem cells and urogenital system) |
| v2 NM_003815 | |||||||
| v3 NM_207194 | |||||||
| v4 NM_207195 | |||||||
| v5 NM_207196 | |||||||
| v6 NM_207197 | |||||||
| v6a AB209157 | |||||||
| v6b AY560599 | |||||||
| v7a AY560600 | |||||||
| v7b AY560601 | |||||||
| v8 AY576417 | |||||||
| ADAM17 | CD156b, MGC71942, TACE, cSVP | NM_003183 | 2p25 | Yes | Yes (NM_009615) | TIMP-3 | Widespread (highest in lymphatic) |
| ADAM18 | ADAM27, MGC41836, MGC88272, tMDCIII | NM_014237 | 8p11.22 | No | Yes (NM_010084) | – | Testis, erythrocytes, bone marrow, pancreas) |
| ADAM19 | FKSG34, MADDAM, MLTNB | v1 NM_023038 v2 NM_033274 | 5q32–q33 | Yes | Yes (NM_009616) | None | Widespread (highest in placenta, mesenchymal stem cells, lymphatic system, heart) |
| ADAM20 | NM_003814 | 14q24.1 | Yes | No | No study | Testis, erythrocytes, bone marrow | |
| ADAM21 | ADAM31, MGC125389 | NM_003813 | 14q24.1 | Yes | Yes (NM_020330) | No study | Testis, erythrocytes, central and peripheral nervous systems |
| ADAM 22 | MDC2, MGC149832 | v1 NM_021723 | 7q21 | No | Yes (NM_001007220, NM_001007221, NM_001098225) | – | Peripheral and central nervous systems |
| v2 NM_021722 | |||||||
| v3 NM_016351 | |||||||
| v4 NM_004194 | |||||||
| v5 NM_021721 | |||||||
| ADAM23 | MDC3 | NM_003812 | 2q33 | No | Yes (NM_011780) | Peripheral and central nervous systems, heart | |
| ADAM28 | ADAM23, MDC-Lm, MDC-Ls, MDCL, eMDC | v1 NM_014265 | 8p21.2 | Yes | Yes (NM_010082, NM_183366) | TIMP-3 | Haematopoietic stem cells, pancreas, gastrointestinal system, bone marrow myeloid cells, lymphatic system, respiratory system, bladder |
| v3 NM_021777 | TIMP-4 | ||||||
| ADAM29 | svph1 | NM_014269 | 4q34 | No | Yes (NM_175939) | – | Testis |
| ADAM30 | svph4 | NM_021794 | 1p13-p11 | Yes | Yes (NM_027665) | No study | Testis |
| ADAM32 | FLJ26299, FLJ29004 | NM_145004 | 8p11.23 | No | Yes (NM_153397) | – | Blood lymphoid cells |
| ADAM33 | RP5-964F7.2, DJ964F7.1, DKFZp434K0521, FLJ35308, FLJ36751, MGC149823, MGC71889 | v1 NM_025220 | 20p13 | Yes | Yes (NM_033615) | TIMP-3 | Uterus, other urogenital system, respiratory system, gastrointestinal system, tongue, endocrine system |
| v2 NM_153202 | TIMP-4 | ||||||
| ADAMDEC1 (ADAM-like, decysin 1) | M12.219 | NM_014479 | 8p21.2 | Yes | Yes (NM_021475) | No study | Lymphatic system, bladder, gastrointestinal system |
Records for ADAM4 and ADAM25 have been discontinued by NCBI.
Also present in Mus musculus Adam4 (NM_009620), Adam4b (EG214321 – predicted gene), Adam24 (NM_010086), Adam25 (NM_011781), Adam26 (NM_010085), Adam31 (AF251559), Adam34 (NM_145745), Adam36 (BN000114), Adam37 (BN000115), Adam38 (NM_001009548), Adam39 (NM_001025380).