Table 2.

ADAM substrates

ADAM	Substrate	References
ADAM-8	ADAM8 (pro-domain cleavage)	Schlomann et al. (2002))
	CD23	Fourie et al., 2003, Moss and Rasmussen, 2007a
	CD30-Ligand (CD153)	Fourie et al., 2003, Moss and Rasmussen, 2007a
	CHL-1	Naus et al. (2004)
	L-selectin	Gomez-Gaviro et al. (2007)
ADAM-9	Pro-HB-EGF	Izumi et al. (1998)
	Amyloid precursor protein (APP)	Koike et al. (1999)
	Kit-ligand	Koike et al. (1999)
	p75 neurotrophin receptor	Koike et al. (1999)
	Insulin B chain	Roghani et al. (1999)
	Delta-like ligand-1 (Dll1)	Dyczynska et al. (2007)
	IGFBP-5	Mohan et al. (2002)
	ADAM-10	Cisse et al. (2005)
	Collagen XVII	Franzke et al. (2004)
	Laminin	Mazzocca et al. (2005)
	Pro-EGF	Peduto et al. (2005)
	FGF Receptor 2 iiib	Peduto et al. (2005)
ADAM-10	Notch	Pan and Rubin (1997)
	Amyloid precursor protein (APP)	Slack et al., 2001, Allinson et al., 2003, Postina et al., 2004
	N-cadherin	Reiss et al. (2005)
	E-cadherin	Maretzky et al. (2005a)
	Proto-cadherin-γ C3 and B4	Reiss et al. (2006)
	VE-cadherin	Schulz et al. (2008)
	CD23	Moss and Rasmussen, 2007a, Weskamp et al., 2006, Lemieux et al., 2007
	Delta-like ligand-1 (Dll1)	Qi et al., 1999, Six et al., 2003
	Pro-EGF	Sahin et al. (2004)
	Pro-betacellulin	Sahin et al. (2004)
	Ephrin A5	Janes et al. (2005)
	c-Met	Kopitz et al. (2007)
	Fas-ligand	Kirkin et al., 2007, Schulte et al., 2007a
	HER2/neu (ERBB2)	Liu et al. (2006)
	CD30	Eichenauer et al. (2007)
	CD44	Nagano et al. (2004)
	Collagen XVII	Franzke et al. (2004)
	TRANCE/RANKL	Hikita et al. (2006)
	L1-CAM	Mechtersheimer et al., 2001, Maretzky et al., 2005b, Gavert et al., 2007
	CX3CL1/Fractalkine	Schulte et al., 2007b, Hundhausen et al., 2007
	CXCL16	Scholz et al., 2007, Schulte et al., 2007b
	LAG-3	Li et al. (2007)
	Desmoglein-2	Bech-Serra et al. (2006)
	Klotho	Chen et al. (2007)
	Cellular prion protein PrPc	Cisse et al. (2005)
	Thyrotopin Receptor (TSHR)	Kaczur et al. (2007)
	Axl	Budagian et al. (2005)
ADAM-12	Delta-like ligand-1 (Dll1)	Dyczynska et al. (2007)
	Gelatin	Roy et al. (2004)
	Type IV collagen	Roy et al. (2004)
	Fibronectin	Roy et al. (2004)
	IGF-BP-3, IGF-BP-5	Loechel et al., 2000, Okada et al., 2008
	HB-EGF	Asakura et al. (2002)
	S-Carboxymethylated transferrin	Jacobsen et al. (2008)
ADAM-15	CD23	Fourie et al. (2003)
	Pro-amphiregulin	Schafer et al. (2004a)
	Pro-HB-EGF	Hart et al. (2005)
	E-cadherin	Najy et al. (2008a)
ADAM-17	Pro-TNF-α	Black et al., 1997, Moss et al., 1997
	Pro-TGF- α	Althoff et al., 2001, Borrell-Pages et al., 2003, Kenny and Bissell, 2007, Peschon et al., 1998, Sahin et al., 2004
	Pro-Amphiregulin	Gschwind et al., 2003, Sahin et al., 2004
	Pro-HB-EGF	Sahin et al., 2004, Schafer et al., 2004a
	Pro-epiregulin	Sahin et al. (2004)
	Neuregulin	Yokozeki et al. (2007)
	Epigen	Sahin and Blobel (2007)
	P75 TNF Receptor	Peschon et al., 1998, Reddy et al., 2000
	P55 TNF Receptor	Reddy et al. (2000)
	IL-1 Receptor-II	Reddy et al. (2000)
	Amyloid precursor protein (APP)	Buxbaum et al., 1998, Slack et al., 2001
	Delta-like ligand-1 (Dll1)	Dyczynska et al. (2007)
	Notch1	Brou et al. (2000)
	TRANCE/RANKL	Lum et al., 1999, Mohan et al., 2002
	Kit ligand-1 and -2	Kawaguchi et al. (2007)
	L-selectin	Peschon et al. (1998)
	Neurotrophin receptor p75NTR	Weskamp et al. (2004)
	TrkA neurotrophin receptor	Diaz-Rodriguez et al. (2002)
	ErbB4/HER4	Maatta et al., 2006, Rio et al., 2000
	CD44	Nagano et al. (2004)
	CD40	Contin et al. (2003)
	CD30	Hansen et al. (2004)
	Growth hormone receptor	Schantl et al., 2004, Zhang et al., 2004
	L1-CAM	Maretzky et al. (2005b)
	VCAM-1	Garton et al., 2003, Singh et al., 2005
	IL6 Receptor	Chalaris et al. (2007)
	Cellular prion protein (PrPc)	Alfa Cisse et al. (2007)
	CX3CL1/Fractalkine	Schulte et al. (2007b)
	LAG-3	Li et al. (2007)
	Colony stimulating factor-1 CSF-1	Horiuchi et al. (2007a)
	Nectin-4	Fabre-Lafay et al. (2005)
	ALCAM	Bech-Serra et al. (2006)
	Desmoglein-2	Bech-Serra et al. (2006)
	Klotho	Chen et al. (2007)
	Vacuolar protein sorting Vps10-p	Hermey et al. (2006)
	N-CAM	Kalus et al. (2006)
	PTP-LAR	Ruhe et al. (2006)
	Collagen XVII	Franzke et al. (2004)
	Pre-adipocyte factor-1 (Pref-1)	Wang and Sul (2006)
	ACE2/ SARS-CoV Receptor	Haga et al., 2008, Lambert et al., 2008, Lambert et al., 2005
	Semaphorin 4D	Zhu et al. (2007)
	NPR (neuronal pentraxin receptor)	Cho et al. (2008)
	MICA/MICB (MHC-class I-related chain A/B	Boutet et al. (submitted for publication)
ADAM-19	Neuregulin	Yokozeki et al. (2007)
	TRANCE/RANKL	Chesneau et al. (2003)
	Pro-TNF-α	Zheng et al. (2004)
	ADAM-19 (in Cys-rich domain)	Kang et al. (2002)
ADAM-28	CD23	Fourie et al. (2003)
	IGFBP-3	Mitsui et al., 2006, Mochizuki et al., 2004
ADAM-33	Kit-ligand-1	Zou et al. (2004)
	CD23	Meng et al. (2007)