Table 3.

Phenotypes of Adam knockout mice

ADAM knockout	Phenotype	References
Adam1a	Male infertility, defects in sperm migration	Nishimura et al. (2004)
Adam2	Male infertility, defects in sperm migration and adhesion	Cho et al., 1998, Nishimura et al., 2001, Nishimura et al., 2007
	Defects in migration of neuroblasts to olfactory bulb	Murase et al. (2008)
Adam3	Male infertility, defects in sperm migration and adhesion	Cho et al., 1998, Kim et al., 2006, Nishimura et al., 2001, Stein et al., 2005
Adam8	Viable, fertile, no pathology (reduced CHL-1 shedding in brain)	Kelly et al. (2005)
Adam9	Viable, fertile, no pathology	Sahin et al. (2004)
Adam10	Early lethality E9.5dpc, defective CNS and heart development, somite formation and vasculogenesis. Phenocopies Notch deficiency (more severe than presenilin 1 and 2 double knockouts.	Hartmann et al. (2002)
Adam11	Viable, fertile, impaired hippocampal-dependent spatial learning and altered nociception responses	Takahashi et al., 2006b, Takahashi et al., 2006a
Adam12	Viable, fertile, 30% embryonic lethality, brown adipose abnormalities, no muscle defect	Kurisaki et al., 2003, Masaki et al., 2005, Sahin et al., 2004
Adam15	Viable, fertile, tumour neovascularization reduced, age onset osteoarthritis	Bohm et al., 2005, Horiuchi et al., 2003, Sahin et al., 2004
Adam17	Perinatal lethality, probably due to heart defects; pulmonary hypoplasia; problems with epithelial tissue maturation, phenocopies defects seen in EGFR, TGFα, HB-EGF and amphiregulin knockout mice	Jackson et al., 2003, Peschon et al., 1998, Shi et al., 2003, Zhao et al., 2001
Adam19	80% postnatal lethality, multiple cardiovascular defects	Horiuchi et al., 2005, Kurohara et al., 2004, Sahin et al., 2004
Adam22	Postnatal lethality, ataxia and peripheral nerve hypomyelination	Sagane et al. (2005)
Adam33	Viable, fertile, no pathology	Chen et al. (2006)