Table III.

Yeast Genes Specifically Involved in the Cvt Pathway and/or Pexophagy

Protein	Cvt	Pexophagy	Step	Role	Organism
Atg11	+	+	Formation/ expansion	Cargo receptor/ adaptor	S.c., P.p., H.p.
Atg19	+	−	Formation/ expansion	Cargo receptor	S.c.
Atg20a	+	+	Formation/ expansion	PtdIns‐3‐P binding protein	S.c.
Atg21b	+	?	Formation/ expansion	PtdIns‐3‐P binding protein	S.c., H.p.
Atg24a	+	+	Formation/ expansion	PtdIns‐3‐P binding protein	S.c., P.p.
Atg25c	−	+	Fusion	Coiled‐coil protein	H.p.
Atg26c	−	+	Vesicle completion	UDP‐glucose:sterol glucosyltransferase	P.p.
Atg27	+	N.D.	Formation/ expansion	PtdIns‐3‐P binding protein	S.c.
Atg28c	−	+	Vesiculation	Coiled‐coil protein	P.p.
Tlg1a	+	N.D.	Formation/ expansion	vSNARE	S.c.
Tlg2a	+	N.D.	Formation/ expansion	tSNARE	S.c.
Vps45a	+	N.D.	Formation/ expansion	Sec1 homolog	S.c.

N.D. = not determined.

A plus or a minus mark indicates whether the protein is required for a pathway. S.c. = Saccharomyces cerevisiae; P.p. = Pichia pastoris; H.p. = Hansenula polymorpha.

^?One report has indicated that Atg21 is essential for pexophagy, another affirms that Atg21 is not required for this process.

^aIn S. cerevisiae, these proteins also catalyze the retrieval transport from early endosomes.

^bAtg21 is not required for pexophagy in S. cerevisiae but is essential for the same process in H. polymorpha.

^cThese factors have no counterparts in S. cerevisiae or the homologs do not have a role in pexophagy.